Antibacterial Screening of Some Synthesized Palmitoyl Amino Acids and Their Aromatic Analogues
نویسندگان
چکیده
Aims: The aims of the research were to synthesize, characterize some palmitoyl amino acids and their aromatic analogues and to screen the synthesized compounds for possible antibacterial activity Study Design: Synthesis, characterization and antibacterial screening of palmitoyl amino acids and their aromatic analogues. Place and Duration of Study: Department of Pharmaceutical and Medicinal Chemistry/ Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, between September 2012 and January 2013. Methodology: Palmitoylchloride was condensed with the respective amino acids (glycine, β-alanine, γ-amino butyric acid) to form the corresponding palmitoyl amino acids. The opening of the isatoic anhydride ring with the three amino acids and subsequent condensation with palmitoyl chloride led to the formation of the amino acid benzamides. The antibacterial screening was carried out using agar well diffusion method. Original Research Article British Journal of Pharmaceutical Research, 4(4): 513-519, 2014 514 Results: All the synthesized compounds were obtained in good yield and high purity; they were unequivocally characterized by the combination IR, H NMR, C NMR and MS. The compounds were however found to possess no antibacterial activity against the tested microorganisms Conclusion: This work has shown that both the straight chain and aromatic analogues of saturated long chain lipid amides are inactive against the tested strains of microorganism.
منابع مشابه
Synthesis of some biologically active 2,4’-bipyridine-5-carbonitriles carrying the 4-Aminohenylthio moiety
A series of new 6-amino-4aryl-2’-[(4-Aminophenyl)thio]-2,4’-bipyridine-5-carbonitriles (3a-h) were synthesized from 4-aminothiophenol (1). The reaction of 4-aminothiophenol with 4-acetyl-2-chloropyridine yielded 1-{2-[(4-aminophenyl)thio]pyridin-4-yl}ethanone(2).Furthertreatment of 2 with aromatic aldehydes in the presence of alcoholic malanonitrile in ammonium acetate gave compounds (3a-h). T...
متن کاملPetra, osiris and molinspiration: A computational bioinformatic platform for experimental in vitro antibacterial activity of annulated uracil derivatives
Annulated pyrano[2,3-d]pyrimidine/pyrano[2,3-d]uracil derivatives were synthesized using aromatic aldehydes, active methylene compounds and barbituric acid in presence of dibutylamine (DBA) catalyst in ethanol as solvent. The different substituents on phenyl ring in the fused pyrano uracil skeleton showed productive influence on its antimicrobial activity against some gram positive and gram neg...
متن کاملFluorinated Aromatic Amino Acids and its Therapeutic Applications
Fluorination became the more radical approach for modification of leading compounds in medicinal chemistry [1,2]. Due to its small size and high electronegativity, fluorine forms a strong covalent bond with carbon, shows a significant impact on neighboring groups that alter the stability and reactivity of the molecules, helps to creates more stable protein folds [3,4]. Fluorinated amino acids w...
متن کاملOn resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity.
The alarming increase in infections caused by multiple drug resistant bacteria including methicillin-resistant Staphylococcus aureus has prompted a desperate search for new antimicrobials. Augmenting the discoveries of completely new scaffolds with antimicrobial activity are efforts aimed at modifying existing molecules to optimize activity or reduce toxicity. We report herein the parallel soli...
متن کاملDesign and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...
متن کامل